MG149 2-[2-(4-heptylphenyl)ethyl]-6-hydroxy-Benzoic acid
MG 149
CAS: 1243583-85-8
Molecular Formula: C22H28O3
MG149 2-[2-(4-heptylphenyl)ethyl]-6-hydroxy-Benzoic acid - Names and Identifiers
MG149 2-[2-(4-heptylphenyl)ethyl]-6-hydroxy-Benzoic acid - Physico-chemical Properties
| Molecular Formula | C22H28O3 |
| Molar Mass | 340.46 |
| Density | 1.100±0.06 g/cm3(Predicted) |
| Boling Point | 477.8±33.0 °C(Predicted) |
| Solubility | 10 mM in DMSO |
| pKa | 3.06±0.30(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | MG149 targets the acetyl-coenzyme A binding site and inhibits acetyltransferase activity in nuclei extracted from tissue samples from different brain regions of mice. MG149 also inhibits p53 and NF-κB signaling pathways. |
MG149 2-[2-(4-heptylphenyl)ethyl]-6-hydroxy-Benzoic acid - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.937 ml | 14.686 ml | 29.372 ml |
| 5 mM | 0.587 ml | 2.937 ml | 5.874 ml |
| 10 mM | 0.294 ml | 1.469 ml | 2.937 ml |
| 5 mM | 0.059 ml | 0.294 ml | 0.587 ml |
Last Update：2024-01-02 23:10:35
MG149 2-[2-(4-heptylphenyl)ethyl]-6-hydroxy-Benzoic acid - Reference Information
| biological activity | MG149 is a potent histone acetyltransferase inhibitor, its IC50 for Tip60 and MOF were 74 μm and 47 μm, respectively. MG149 (Tip60 HAT inhibitor) is a potent histone acetyl transfer inhibitor with IC50 of 74 μm and 47 μm for Tip60 and MOF, respectively. |
| Target | Value |
| MOF (Cell-free assay) | 47 μM |
| Tip60 (Cell-free assay) | 74 μM |
Last Update：2024-04-09 19:05:17
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CAS: 1243583-85-8
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CAS: 1243583-85-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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